Alcat Scientific Dossier
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Understanding Your Results
Gut Health Profile (GHP)
GHP - What is it?
The new Gut Health Profile (GHP) from Cell Science Systems is the most comprehensive Celiac & Gluten Sensitivity screening tool available as it combines genetic, antibody and cellular analysis into one convenient test.
HLA Typing for Celiac Disease –HLA -DQ2.5 and HLA-DQ8
Strong evidence shows that in order to develop celiac disease, a person must have one or both of two genetics known as HLA-DQ2.5 and HLA-DQ8. More than 95% of patients with celiac disease have at least one of the two genetics. Most patients (more than 90%) carry the DQ2 genetic.
Total Serum IgA
It is not uncommon for CD patients to be IgA deficient. It is not only the most common immunologic deficiency ( 1:400-1:700 in the general population and 1:50 in CD patients) but may be the single largest contributor to false negative results in biopsy confirmed CD patients. It is used as a metric to qualify IgA testing for tTG and DGP antibody levels and when shown to be low or deficient why it is important to check IgG levels for both tTG and DGP.
Tissue Transglutaminase Antibody (tTG) - IgA & IgG
Measuring tissue transglutaminase antibody (tTg) is extremely useful as it is produced in the small intestine where gluten causes initial inflammation in sensitive people. It is often recommended as an initial test for Celiac Disease (CD) because of its high sensitivity (measuring the proportion of actual positives which are currently identified as such) and high specificity (measuring the proportion of actual negatives which are correctly identified as such) for CD.
Deamidated Gliadin Peptide (DGP) Antibody - IgA & IgG
This test detects antibodies binding synthetic deamidated gliadin-related peptides (DGP). Selective deamidation specifically increases the circulating antibody recognition of gliadin related peptides in CD patients. It is both highly sensitive and highly specific for active CD. Its high specificity is similar to that shown for tTG and even greater than that shown for previously tested antigliadin antibody (AGA).
Anti-Saccharomyces Cerevisiae Antibody (ASCA)
Because of an overlap with inflammatory bowel disease (IBD), specifically Crohn's Disease, (with patients showing gastrointestinal symptoms) the GHP includes ASCA. A positive ASCA test is associated with Crohn's Disease (59%-63%).
ALCAT Food Sensitivity/Intolerance
The ALCAT Test is used to reveal innate immune system response to ingestion of common offending foods, often associated with GI inflammation, reflecting sensitivity/intolerance on a cellular level.
Gluten Containing Grains: Gluten/Gliadin, Barley, Malt, Spelt, Rye & Wheat
Non-Gluten Containing Grains: Amaranth, Quinoa, Oat, Sorghum, Rice, Corn, Millet, Buckwheat & Wild Rice