Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression
Discussion: Interindividual variation in immune responses is accompanied by diverging patterns of gene regulation dependent on underlying genotype.
Benjamin P. Fairfax,* Peter Humburg, Seiko Makino, Vivek Naranbhai, Daniel Wong, Evelyn Lau, Luke Jostins, Katharine Plant, Robert Andrews, Chris McGee, Julian C. Knight*
Many genetic variants associated with common disease susceptibility occur close to immune- related genes in noncoding DNA, suggestive of a regulatory function.
Chronic inflammation as a determinant of future aging phenotypes.
Interpretation: Chronic inflammation, as ascertained by repeat measurements, was associated with a range of unhealthy aging phenotypes and a decreased likelihood of successful aging.
Tasnime N. Akbaraly PhD, Mark Hamer PhD, Jane E. Ferrie PhD, Gordon Lowe DSc, G. David Batty PhD,Gareth Hagger-Johnson PhD, Archana Singh-Manoux PhD, Martin J. Shipley MSc, Mika Kivimäki PhD.
The importance of chronic inflammation as a determinant of aging phenotypes may have been underestimated in previous studies that used a single measurement of inflammatory markers.
Spectrum of gluten-related disorders: consensus on new nomenclature and classification.
Conclusions: It is now becoming apparent that reactions to gluten are not limited to CD, rather we now appreciate the existence of a spectrum of gluten-related disorders.
Anna Sapone1,2, Julio C Bai3, Carolina Ciacci4, Jernej Dolinsek5, Peter HR Green6, Marios Hadjivassiliou7,Katri Kaukinen8, Kamran Rostami9, David S Sanders10, Michael Schumann11, Reiner Ullrich11, Danilo Villalta 12,Umberto Volta13, Carlo Catassi1,14 and Alessio Fasano1*
A decade ago celiac disease was considered extremely rare outside Europe and, therefore, was almost completely ignored by health care professionals. In only 10 years, key milestones have moved celiac disease from obscurity into the popular spotlight worldwide. Now we are observing another interesting phenomenon that is generating great confusion among health care professionals.
ALCAT | Available for over 25 years
The Alcat Test is now considered the, "gold standard" laboratory method for identification of non-IgE mediated reactions to foods, chemicals, and other categories of substances Read More
The Gut Health Profile (GHP) is the latest and most comprehensive way to learn about your body's reaction to gluten. Celiac disease affects 1 in 133 people, and of those, approximately 95% are undiagnosed! Read More
In our ongoing efforts to offer valuable diagnostic testing to our providers, Cell Science Systems is presenting new specialized assays that expand the boundaries of critical knowledge needed to improve the health of your patients. These assays includes Lymphocyte Telomere Length (LTL), MTHFR Genetic Mutation, Vitamin D and Adrenal Stress Profile. Read More